顾瑞霞  

1 博士 东北农业大学 食品科学专业（2000年）

2 主要论文

发表论文200余篇，专利37项。

近5年主要论文：

(1) Chenchen Zhang, Jingyu Lu, Duo Yang, Xia Chen, Yujun Huang, Ruixia Gu*, Stress influenced the aerotolerance of Lactobacillus rhamnosus hsryfm 1301, Biotechnology Letters, 2018, 40(4):729-735.

(2) Dawei Chen, Zhenquan Yang, Xia Chen, Yujun Huang, Boxing Yin, Feixiang Guo, Haiqing Zhao, Tangyan Zhao, Henxian Qu, Jiadi Huang, Yun Wu, Gu Ruixia*. The effect of Lactobacillus rhamnosus hsryfm 1301 on the intestinal microbiota of a hyperlipidemic rat model. BMC Complementary and Alternative Medicine, 2014, 14: 386-394.

(3) Dawei Chen, Zhenquan Yang, Xia Chen, Yujun Huang, Boxing Yin, Feixiang Guo, Haiqing Zhao, Jiadi Huang, Yun Wu, Gu Ruixia*. Effect of Lactobacillus rhamnosus hsryfm 1301 on the Gut Microbiota and Lipid Metabolism in Rats Fed a High-Fat Diet. Journal of Microbiology and Biotechnology, 2015, 25(5): 687-695.

(4) Yin Xu, Xia Chen, Maolin Lu, Zhenquan Yang,Yujun Huang, Dong Liu, Lixia Xiao,Yun Sun, Wenjin Gu, Defeng Xu, Ruixia Gu*. In vitro and in vivo studies on the antioxidant effects of soymilk fermented with Streptococcus thermophilus grx02. Food Biotechnology.2012,26(4):1-12

(5) 陈大卫, 顾瑞霞*, 鲁茂林, 黄玉军, 张臣臣, 关成冉, 张玉律, 范晨雨.人源乳酸菌耐酸耐胆盐能力及降胆固醇作用研究.食品与机械,2017,33(10):1-5.

(6) 戴颖, 瞿恒贤, 瓦云超, 黄玉军, 陈霞, 陈大卫, 杨振泉, 顾瑞霞*, 发酵条件对胆固醇降解能力的影响, 食品工业科技. 2017, 38(12): 123- 128.

(7) 蒋欣容, 瞿恒贤, 陈大卫, 陈霞, 黄玉军, 印伯星, 杨振泉, 顾瑞霞*, 乳酸菌混合发酵对抑菌作用的影响研究. 中国乳品工业, 2017, 45(9): 11-16.

(8) 刘东方, 薛梅, 桑建, 陈大卫, 何勇, 李正华, 王春雷, 顾瑞霞*, 高黏附性乳酸菌的筛选及其对免疫细胞活性影响的研究. 中国微生态学杂志, 2016, 28(8): 869-874.

    (9) 赵志文, 戴颖, 王琴, 张奇波, 陈霞, 黄玉军, 陈大卫, 顾瑞霞*, 单一及组合乳酸菌对发酵乳功能特性的影响. 食品工业科技, 2016, 37(17): 335- 339.

(10) 薛梅, 刘东方, 桑建, 陈大卫, 张博文, 何勇, 李正华, 王春雷, 顾瑞霞*, 鼠李糖乳杆菌LV108传代的稳定性. 中国乳品工业, 2016, 44(7): 15-19.

(11) 瓦云超, 赵海晴, 李仁芳, 刘演景, 伍云, 孙宁, 王琴, 张奇波, 于凡, 顾瑞霞*.热处理对水牛乳物化性质的影响.中国乳品工业,2016,44(05):15-17.

(12) 陈霞, 包一枫, 陈大卫, 赵海晴, 顾瑞霞*.原料乳中氧氟沙星残留量对Streptococcus thermophilus grx02发酵乳质构及流变特性的影响.食品科学, 2015,36(23):18-22.

(13) 郭飞翔, 陈大卫, 瞿恒贤, 陈旭娇, 陈娜, 李朋, 顾瑞霞*.人源益生菌研究与应用开发进展.中国乳品工业,2014,42(08):27-31+41.

(14) 黄玉军, 刘冬, 赵兰凤, 顾瑞霞*, 6株人源乳酸菌体外抗氧化活性的比较, 现代食品科技. 2013, 29(7): 1518-1522.

(15) 黄玉军, 梁文星, 刘冬, 陈大卫, 卢俭, 顾瑞霞*.长寿人群肠道具有降胆固醇特性益生菌的筛选.中国乳品工业,2013,41(12):13-16.

(16) 陈大卫, 郭飞翔, 顾瑞霞*, 赵海晴.人源乳酸菌体外降胆固醇的影响因素研究.食品工业科技,2013,34(23):58-61+69.

(17) 徐寅, 黄玉军, 陈霞, 鲁茂林, 顾瑞霞*.牛乳含量对发酵豆乳风味成分的影响.食品科学,2013,34(04):1-5.

(18) 徐寅, 黄玉军, 陈霞, 刘冬, 顾瑞霞*.乳酸菌发酵豆乳体内外抗氧化效应研究.中国乳品工业,2012,40(08):16-19.

(19) 陈霞, 吴琳楠, 黄玉军, 陈大卫, 顾瑞霞*.环丙沙星残留量对嗜热链球菌grx02发酵乳品质的影响.食品科学,2012,33(13):176-179.

(20) 徐寅, 黄玉军, 顾瑞霞*, 陈霞, 郭飞翔, 陆春良, 鲁茂林.乳酸菌对发酵豆乳风味成分的影响.食品与发酵工业,2012,38(05):91-95.

近5年主要授权专利：

(1) 顾瑞霞, 孟茜, 赵堂彦, 黄玉军, 印伯星. 一种具有α-葡萄糖苷酶抑制作用的鹰嘴豆乳饮料及其制备方法. 2017.12.26, 中国, ZL201410543578.1（已转让）

(2) 顾瑞霞, 赵兰凤, 赵志文, 黄玉军, 陈霞, 陈大卫, 蒋欣荣, 瓦云超, 孟茜, 一种具有润肠通便和辅助降血脂功能的益生菌发酵乳饮料及其制作方法, 2017.10.24, 中国, ZL201510150600.0

(3) 顾瑞霞, 陈大卫, 伍云, 黄嘉棣, 谢秉锵, 孙宁, 源于广西巴马长寿村的鼠李糖乳杆菌在辅助降血脂方面的应用, 2016.05.25, 中国, ZL201410122292.6 （已转让）

(4) 顾瑞霞, 刘东, 黄玉军, 陈霞, 陈大卫, 郭飞翔, 赵堂彦, 蒋欣荣, 人源发酵乳杆菌grx07及其应用, 2016.07.13, 中国,  ZL201410156237.9 （已转让）

    (5) 孟茜, 顾瑞霞, 王华, 王琴, 许珊珊, 蒋欣荣, 陈霞, 赵堂彦, 一种风味发酵豆乳配方及制备方法, 2016.04.27, 中国, ZL201410270743.0（研究生第一，已转让）

    (6) 孟茜, 王琴, 王华, 顾瑞霞, 许珊珊, 蒋欣荣, 赵堂彦, 陈霞, 用于发酵豆乳的乳酸菌组合发酵剂, 2016.04.13, 中国, ZL201410270744.5（研究生第一，已转让）

(7) 顾瑞霞, 陈大卫, 伍云, 黄嘉棣, 谢秉锵, 孙宁,  邹东昊, 蒋欣荣, 源于广西巴马长寿村的益生菌鼠李糖乳杆菌hsryfm1301及其应用, 2015.10.21, 中国, ZL201310751034.X  （已转让）

(8) 顾瑞霞, 丁缪华, 陈旭娇, 陈霞, 黄玉军, 鼠李糖乳杆菌grx19及其应用, 2015.08.26, 中国, ZL201110441666.7

(9) 顾瑞霞, 黄玉军, 梁文星, 陈霞, 陈大卫,  郭飞翔, 具有辅助降血脂功能的发酵乳杆菌grx08及其应用, 2014.11.26, 中国, ZL201310309222.7 （已转让）

(10) 顾瑞霞, 郭飞翔, 吴晨晨, 黄玉军, 陈霞, 印伯星, 徳氏乳杆菌保加利亚亚种grx33及其在发酵乳制备中的应用, 2014.11.05, 中国, 201310310725.6

(11) 顾瑞霞, 徐寅, 韩澄, 陈霞, 黄玉军, 一种多菌株高活性乳酸菌饮料的制备方法, 2013.06.19, 中国, ZL201110173156.6

(12) 顾瑞霞, 朱小红, 杨振泉, 王慧晶, 张宜凤, 具有降胆固醇及抑菌能力的鼠李糖乳杆菌grx10及其用途, 2013.07.24, 中国, ZL200810023014.X

(13) 顾瑞霞, 徐寅, 刘彩平. 一种新型发酵豆乳制品的制备方法,2012.05.30, 中国, ZL2010101394657

(14) 顾瑞霞, 徐寅, 韩澄, 刘梅. 一种乳酸菌发酵的抑菌剂及其制备方法,2012.12.26, 中国, ZL201110003356.7

(15) 顾瑞霞, 徐寅, 管敏敏, 黄玉军. 一种发酵型卤味即食豆干的制备方法,2012.11.28, 中国, ZL201110173158.5（已转让）

3 邮箱

rxgu@yzu.edu.cn

4 照片

5 其他信息

江苏省乳品生物技术与安全控制重点实验室主任

江苏扬州现代乳业加工服务中心主任

中国畜产品加工研究会乳品加工专业委员会副主任

教育经历：

(1) 1998.9–2000.12, 东北农业大学, 食品科学, 博士, 导师: 骆承庠；

(2) 1983.9–1987.7, 江苏农学院, 农畜产品贮藏与加工工程, 学士。

科研与学术工作经历：

(1) 2003.8-至今, 扬州大学, 食品科学, 教授；

(2) 1995.7-2003.7, 扬州大学, 食品科学, 副教授；

(3) 1993.7-1995.6, 江苏农学院, 食品科学, 讲师；

(4) 1987.8-1993.6, 江苏农学院, 食品科学, 助教。

研究方向：

(1) 乳制品加工技术；

(2) 乳酸菌应用技术；

(3) 乳酸菌基础研究。

主讲课程：

博士研究生《动物食品科学技术研究进展》；

硕士研究生《食品加工高新技术基础》；

本科生《乳品科学与技术概论》、《乳品加工工艺学》 。

科研奖励与项目：

荣获省部级科研奖励9项（其中主持6项）。主持863、国家自然科学基金、科技部“十五”、“十一五”、“十二五”重大科技支撑等省部级课题26项。

在研项目：

(1) 国家自然科学基金，外源益生菌对肠道拟杆菌和乳杆菌调控及对肝细胞脂质氧化损伤拮抗机制研究(2016-2019年)。

(2) 广西科技厅科学研究与技术开发计划，功能性多菌株益生菌发酵乳加工关键技术研究与新产品开发(2016-2018年)。

Ruixia Gu  

1 Doctor Food Science, Northeast Agricultural University (2000).

2 Papers:

More than 200 papers and 37 licensed patents.

Papers published in the last five years:

(1) Chenchen Zhang, Jingyu Lu, Duo Yang, Xia Chen, Yujun Huang, Ruixia Gu*, Stress influenced the aerotolerance of Lactobacillus rhamnosus hsryfm 1301, Biotechnology Letters, 2018, 40(4):729-735.

(2) Dawei Chen, Zhenquan Yang, Xia Chen, Yujun Huang, Boxing Yin, Feixiang Guo, Haiqing Zhao, Tangyan Zhao, Henxian Qu, Jiadi Huang, Yun Wu, Gu Ruixia*. The effect of Lactobacillus rhamnosus hsryfm 1301 on the intestinal microbiota of a hyperlipidemic rat model. BMC Complementary and Alternative Medicine, 2014, 14: 386-394.

(3) Dawei Chen, Zhenquan Yang, Xia Chen, Yujun Huang, Boxing Yin, Feixiang Guo, Haiqing Zhao, Jiadi Huang, Yun Wu, Gu Ruixia*. Effect of Lactobacillus rhamnosus hsryfm 1301 on the Gut Microbiota and Lipid Metabolism in Rats Fed a High-Fat Diet. Journal of Microbiology and Biotechnology, 2015, 25(5): 687-695.

(4) Yin Xu, Xia Chen, Maolin Lu, Zhenquan Yang,Yujun Huang, Dong Liu, Lixia Xiao,Yun Sun, Wenjin Gu, Defeng Xu, Ruixia Gu*. In vitro and in vivo studies on the antioxidant effects of soymilk fermented with Streptococcus thermophilus grx02. Food Biotechnology.2012,26(4):1-12

(5) Dawei Chen, Ruixia Gu*, Maolin Lu, Yujun Huang, Chenchen Zhang, Chengran Guan, Yulu Zhang, Chenyu Fan. Acid and bile salt resistance of human lactic acid bacteria and its cholesterol lowering effect. Food and Machinery, 2017, 33(10):1-5.

(6) Ying Dai , Hengxian Qu, Yunchao Wa, Yujun Huang, Xia Chen , Dawei Chen, Zhenquan Yang, Ruixia Gu*. Effects of fermentation conditions on cholesterol degradability, Food Industry Technology. 2017, 38(12): 123- 128.

(7) Xinrong Jiang, Hengxian Qu, Dawei Chen, Chen Xia, Yujun Huang, Boxing Yin, Zhenquan Yang, Ruixia Gu*. Study on bacteriostatic activity of mixed cultivation of lactic acid bacteria. China Dairy Industry, 2017, 45(9): 11-16.

(8) Dongfang Liu, Mei Xue, Jian Sang, Dawei Chen, Yong He, Zhenhua Li, Chunlei Wang, Ruixia Gu*. Screening of lactic acid bacteria with high adhesion and its effect on the activity of immune cells. Chinese Journal of Microecology, 2016, 28(8): 869-874.

(9) Zhiwen Zhao, Ying Dai, Qin Wang, Qibo Zhang, Xia Chen, Yujun Huang, Dawei Chen, Ruixia Gu*. Study on the effect of single and mixed lactic acid bacteria on functional properties of fermented milk. Food Industry Technology, 2016, 37(17): 335- 339.

(10) Mei Xue, Dongfang Liu, Jian Sang, Daiwei Chen, Bowen Zhang, Yong He, Zhenghua Li, Chunlei Wang, Ruixia Gu*. Research on subculture and genetic stability of Lactobacillus rhamnosus LV108. China Dairy Industry, 2016, 44(7): 15-19.

(11) Yunchao Wa, Haiqing Zhao, Renfang Li, Yanjing Liu, Yun Wu, Ning Sun, Qin Wang, Qibo Zhang, Fan Yu, Ruixia Gu*. Effect of heat treatment on the physicochemical properties of buffalo milk. China Dairy Industry, 2016, 44(05): 15-17.

(12) Xia Chen, Yifeng Bao, Dawei Chen, Haiqing Zhao, Ruixia Gu*. Effect of Residual Ofloxacin in Raw Milk on Texture and Rheological Behavior of Fermented Milk Produced by Streptococcus thermophilus grx02. Food Science, 2015, 36(23): 18-22.

(13) Feixiang Guo, Dawei Chen, Hengxian Qu, Xujiao Chen, Nan Chen, Peng Li, Ruixia Gu*. Review on research and application of probiotics origin from human. China Dairy Industry, 2014, 42(08): 27-31+41.

(14) Yujun Huang, Dong Liu, Lanfeng Zhao, Ruixia Gu*. In Vitro Antioxidant Activities of Six Lactic Acid Bacteria Isolated from Human Intestinal Tract. Modern Food Technology. 2013, 29(7): 1518-1522.

(15) Yujun Huang, Wenxing Liang, Dong Liu, Dawei Chen, Jian Lu, Ruixia Gu*. Screening of cholesterol-reducing probiotic isolated from the intestine of the longevity crowd in vitro. China Dairy Industry, 2013, 41(12): 13-16.

 (16) Dawei Chen, Feixiang Guo, Ruixia Gu*, Haiqing Zhao. Studying on influencing factors of human origin lactic acid bacteria for cholesterol-lowering in vitro. Food Industry Technology, 2013, 34(23): 58-61+69.

(17) Yin Xu, Yujun Huang, Xia Chen, Maolin Lu,Ruixia Gu*. Influence of Milk Content on Flavor Compounds in Fermented Soymilk. Food Science, 2013, 34(04): 1-5.

 (18) Yin Xu, Yujun Huang, Xia Chen, Dong Liu, Ruixia Gu*. In vitro and in vivo studies on the antioxidant effects of soymilk fermented with lactic acid bacteria.  China Dairy Industry, 2012, 40(08): 16-19.

(19) Chen xia, Linnan Wu, Yujun Huang, Dawei Chen, Ruixia Gu*. Effect of Ciprofloxacin Residue on Quality of Streptococcus thermophilus grx02 Fermented Milk. Food Science, 2012, 33(13): 176-179.

(20) Yin Xu, Yujun Huang, Ruixia Gu*, Xia Chen, Feixiang Guo, Chunliang Lu, Maolin Lu. Effect of lactic acid bacteria on flavor components of fermented soymilk. Food and Fermentation Industry, 2012, 38(05): 91-95.

Patents licensed in the last five years：

(1) Ruixia Gu, Qian Meng, Tangyan Zhao, Yujun Huang, Boxing Yin. The invention discloses a hummus milk beverage with enzyme-glucosidase inhibition and a preparation method thereof. 2017.12.26, China, ZL201410543578.1

(2) Ruixia Gu, Lanfeng Zhao, Zhiwen Zhao, Yujun Huang, Xia Chen, Dawei Chen, Xinrong Jiang, Yunchao Wa, Qian Meng, Probiotic fermented milk beverage with moistening bowel and purgation and auxiliary blood fat lowering function and preparation method thereof, 2017.10.24, China, ZL201510150600.0

(3) Ruixia Gu, Dawei Chen, Yun Wu, Jiadi Huang, Bingqiang Xie, Ning Sun, Application of Lactobacillus rhamnosus isolated from Bama longevity village in Guangxi, 2016.05.25, China, ZL201410122292.6  

(4) Ruixia Gu, Dong Liu, Yujun Huang, Xia Chen, Dawei Chen, Feixiang Guo, Tangyan Zhao, Xinrong Jiang, Lactobacillus fermentum grx07 and its application, 2016.07.13, China, ZL201410156237.9

(5) Ruixia Gu, Dawei Chen, Yun Wu, Jadi Huang, Bingqiang Xie, Ning Sun, Donghao Zou, Xinrong Jiang, Lactobacillus rhamnosus hsryfm1301 from the longevity village of Bama in Guangxi and its application, 2015.10.21, China, ZL201310751034.X

(6) Qian Meng, Ruixia Gu, Hua Wang, Qin Wang, Shanshan Xu, Xinrong Jiang, Xia Chen, Tangyan Zhao. Formula and preparation method of a fermented soymilk with special flavour. 2016.04.27, China, ZL201410270743.0

(7) Qian Meng, Qin Wang, Hua Wang, Ruixia Gu, Shanshan Xu, Xinrong Jiang, Tangyan Zhao, Xia Chen. A kind of combination lactic acid bacteria starter for fermented soymilk. 2016.04.13, China, ZL201410270744.5.

(8) Ruixia Gu, Miaohua Ding, Xujiao Chen, Xia Chen, Yujun Huang, Lactobacillus rhamnosus grx19 and its application, 2015.08.26, China, ZL201110441666.7

(9) Ruixia Gu, Yujun Huang, Wenxing Liang, Xia Chen, Dawei Chen, Feixiang Guo, Lactobacillus fermentum grx08 with auxiliary blood lipid lowering function and its application, 2014.11.26, China, ZL201310309222.7

(10) Ruixia Gu, Feixiang Guo, Chenchen Wu, Yujun Huang, Xia Chen, Boxing Yin, Lactobacillus delbrueckii subsp. bulgaricus grx33 and its application in fermentation milk preparation, 2014.11.05, China, 201310310725.6

(11) Ruixia Gu, Yin Xu, Cheng Han, Xia Chen, Yujun Huang, Preparation method of multi strains high activity lactobacillus beverage, 2013.06.19, China, ZL201110173156.6

(12) Ruixia Gu, Xiaohong Zhu, Zhenquan Yang, Huijing Wang, Yifeng Zhang. Lactobacillus rhamnosus grx10 with cholesterol lowering and bacteriostatic ability and its uses, 2013.07.24, China, ZL200810023014.X

(13) Ruixia Gu, Yin Xu, Caiping Liu. Preparation of a new fermented soybean milk product, 2012.05.30, China, ZL2010101394657

(14) Ruixia Gu, Yin Xu, Cheng Han, Mei Liu. Bacteriostatic agent for lactic acid bacteria fermentation and preparation method thereof, 2012.12.26, China, ZL201110003356.7

(15) Ruixia Gu, Yin Xu, Minmin Guan, Yujun Huang. Preparation method of fermented instant stewed dried bean curd, 2012.11.28, China, ZL201110173158.5

3 E-mail

   rxgu@yzu.edu.cn

4 Photo

5 Other information

Director of Jiangsu Key Laboratory of Dairy Biotechnology and Safety Control

Director of Jiangsu Yangzhou Modern Dairy Processing Service Center

Deputy director of Dairy Processing Committee, Chinese Association of Animal Products Processing

Educational experience：

1998/09-2000/12, Northeast Agricultural University, Food Science, Doctor

1983/09-1987/07, Jiangsu Agricultural College (Predecessor of Yangzhou University), Agricultural Product Storage and Process Engineering, Bachelor

Work experience：

2003/08-now, Yangzhou University, Food Science, Professor

1995/07-2003/07, Yangzhou University, Food Science, Associate Professor

1993/07-1995/06, Jiangsu Agricultural College, Food Science, Lecturer

1987/07-1993/06, Jiangsu Agricultural College, Food Science, Assistant

Research area:

(1) Processing technology of dairy products;

(2) Application of lactic acid bacteria;

(3) Basic research of lactic acid bacteria.

Course

Research Progress of Animal Food Science and Technology

New and High Technology Base of Food Processing

Introduction to Dairy Science and Technology, Dairy Processing

Achievement and Projects

Win 9 research awards of provincial and ministerial level (6 awards as lead author). Complete 26 scientific research projects above provincial level.

Ongoing Projects:

(1) National Natural Science Foundation of China. Investigation on effect and mechanism of antagonism of lipid oxidation to hepatocyte by probiotics from external to regulate Bacteroides and Lactobacillus in intestinal (2016-2019).

(2) Scientific Research and Technology Development Plan of Guangxi Science and Technology Office. Key technology research and new product development of functional multi-strain fermented milk probiotics (2016-2018).